With over 30 million treatments worldwide and counting, the Restylane line of hyaluronic acid fillers provides natural-looking results by smoothing away facial wrinkles and folds (Restylane, Restylane Lyft, Restylane Refyne, Restylane Defyne), providing subtle lip enhancement and smoothing the lines around them (Restylane Silk), and adding lift and volume to the cheeks (Restylane Lyft).
Our latest addition to the family — Restylane Refyne and Restylane Defyne — is designed with next-generation technology to help provide natural-looking results with flexibility that helps maintain natural expression in motion.
Frequently Asked Questions
What is Restylane?
With over 30 million treatments worldwide and counting,1 the Restylane line of hyaluronic acid fillers provides natural-looking results by smoothing away facial wrinkles and folds (Restylane,4 Restylane Lyft,5 Restylane Refyne,2 Restylane Defyne3), providing subtle lip enhancement and smoothing the lines around them (Restylane Silk6), and adding lift and volume to the cheeks (Restylane Lyft5).
The good news is that you can do something about the signs of facial aging with a product in the Restylane family — to help reveal a younger-looking you. That means you get minimally invasive, clinically proven, natural-looking results to help achieve the look you want. Talk to your healthcare provider today to determine if the Restylane family of products is right for you.
- Restylane® Silk is for lip augmentation and for correction of perioral wrinkles
- (Restylane Lyft) add lift and volume to the cheeks and facial wrinkles and folds
Restylane® Lyft with Lidocaine is for deep implantation into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds and for cheek augmentation and for the correction of age-related midface contour deficiencies
- Restylane® Refyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds
- Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds
Are there any reasons why I should not use products within the Restylane® family?
To ensure a safe procedure, your doctor will talk to you about your medical history to determine if you are an appropriate candidate for treatment. You should not use products within the Restylane family if:
You have severe allergies with a history of severe reactions (anaphylaxis)
You are allergic to lidocaine or to any of the gram-positive bacterial proteins used to make hyaluronic acid
You are prone to bleeding or have been diagnosed with a bleeding disorder
Tell your doctor if you are breastfeeding, pregnant, or trying to become pregnant. The safety of these products for use during pregnancy, or in women who are breastfeeding, has not been studied
Restylane, Restylane-L, Restylane® Lyft with Lidocaine, Restylane Refyne and Restylane Defyne are intended to treat facial wrinkles and folds, such as nasolabial folds. Restylane and Restylane-L are also intended for lip enhancement. Treatments in other areas of the face have not been evaluated in clinical studies.
The safety and effectiveness of Restylane® Silk for areas other than the lips and perioral area have not been evaluated in clinical studies
Tell your doctor if you have any history of scarring, particularly thick and stiff scars, or any pigmentation (skin color) disorders. These side effects can occur with hyaluronic acid fillers in general.
Tell your doctor if you are planning other laser treatments or a chemical peel, as there is a possible risk of inflammation at the treatment site if these procedures are performed after treatment
Patients who experience skin injury near the site of injection with these products may be at a higher risk for side effects
Tell your doctor if you are on any medications to decrease your body’s immune response (immunosuppressive therapy). Using these medications may increase your risk of bruising or bleeding at the gel injection site.
Tell your doctor if you are using any “blood thinners” such as aspirin, warfarin, or any other medications that affect bleeding. Using these medications may increase your risk of bruising or bleeding at the gel injection site.
The use of these products on gel injection sites with skin sores, pimples, rashes, hives, cysts, or infections should be postponed until healing is complete. Use of product in these areas could delay healing or make your skin problems worse.
What are the possible side effects?
The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, and itching at the injection site. These are typically mild in severity and typically resolve in less than 7 days in nasolabial folds and less than 14 days in lips. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site.
One of the risks with using this product is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin.
As with all skin injection procedures, there is a risk of infection.
Pre & Post Treatment Care
Ingestion of alcoholic beverages prior to treatment can increase the chances of bruising and/or swelling. No anti-inflammatory drugs (Ibuprofen, Motrin, Advil, Aleve, Vioxx, etc.), aspirin, Vitamin E, or Ginko Biloba one week prior to treatment. This will reduce the possible side effects of bruising and/or swelling in area(s) of treatment. You cannot be pregnant or breastfeeding to receive treatment. You cannot be allergic to eggs or egg products to receive treatment.
Do not lie down for 2 to 4 hours following treatment. Facial exercises (squint/frown/smile) are strongly recommended in the treated area for one hour after injection. Avoid manipulation of treated area for a minimum of four hours. By following the above measures you will minimize the occurrence of ptosis (droopy eyelids), bruising, and less than optimal outcomes. Common side effects include a slight headache lasting a few hours up to 48 hours, and temporary bruising and/or swelling.
Treatment effect will take 2 to 10 days. Benefits of treatment may last 3 to 6 months; the average is 4 months. Please inform the office if the resolution of the lines has not taken effect in 10 days. Additional unit of BOTOX®® Cosmetic may be necessary to achieve desired result. Follow up treatments should be scheduled prior to return of full movement of muscle, usually at three months. Consistent repeated treatments will produce the best resolution of wrinkles.